Formula of Depression

Mental health is as much important as physical wellbeing. Centuries back depression was known as Melancholy.Since depression itself is hard to diagnosis , science has to come up with a very different way to diagnosis the so called mental health.

Depression is still a topic that. is not openly discussed in society . By no means, it is a conversation either our society in Nepal tends to avoid the whole topic about mental issues or they think the poor fellow is crash and insane.Luckily things are changing the people have realized the realized the impotence of mental health as well. It really hurts me to see and read a man chained up in a goat shed for 15 plus years

is this humane way to treat mental disorder

Anyway, if we dig deep in this topic of mental disorder it will be a huge and massive article, plus there language that they use are out of out context and there will be a need of constant medical dictionary .One of my very personal friend works at CMC Nepal, they do a lots of works regrading educating the public about the mental health, how they should be treated.

Her profile can be found on is a very pro-active member in that and personally I know her very well and she is kind of some that you can trust with confidence.Personally, she has helped me as well in what was in her reach.In her own words she says’

IT’s OKAY – to make mistakes- to have a bad day- to be less than perfect- to do what’s best for your- to be YOURSELFMental Health for All- Greater Investment, Greater Access- everyone, everywhere”

Depression scoring system

A depression score is equivalent to the level of 2-methoxy-4-hydromadei acid plus the level of norepinephrine, minus the level of normetaneperine, the sum of those divided by the level of 3-methoxy-4-hydroxymandelic acid,4-hydroxyphenylgilcol=a compound found in the urine of all the people and not apparently affected by depression


CTP puts it “D type scoreZ=



Let me clear your head out of this once again,
C1=The cervical spine is made up of 7 vertebrae. The first 2, C1 and C2, are highly specialized and are given unique names: atlas and axis, respectively. C3-C7 are more classic vertebrae, having a body, pedicles, laminae, spinous processes, and facet joints

MHPG=3-Methoxy-4-hydroxyphenylglycol (MHPG) is the major metabolite of norepinephrine in the brain (77), although the amount of MHPG excreted in the urine that is derived from metabolism of brain norepinephrine remains controversial (78,79). Reports of MHPGexcretion in unipolar depressed patients are inconsistent.

NMN=NMN is made from B vitamins in the body, and is a molecule naturally occurring in all life forms. Like nicotinamide riboside, NMN is a derivative of niacin, and humans have enzymes that can use NMN to generate nicotinamide adenine dinucleotide (NADH).

MN=membranous nephropathy

VMA= Vanillylmandelic acid (VMA) is one of the breakdown products (metabolites) of epinephrine (adrenaline) and norepinephrine. Epinephrine and norepinephrine belong to a group of similar hormones called catecholamines. ... The primary catecholamines released are dopamine, epinephrine, and norepinephrine.

Co=Carboxylation is a chemical reaction in which a carboxylic acid group is produced by treating a ... Carboxylation in biochemistry includes a posttranslational modification of glutamate residues, to γ-carboxyglutamate, ... "Frontiers, Opportunities, and Challenges in Biochemical and Chemical Catalysis of CO2 Fixation". 

VA=the volume of gas that reaches the alveoli per unit time e use the alveolar ventilation equation which states; alveolar ventilation (VA) equals VT minus physiologic dead space (VD) multiplied by RR.

NE=Norepinephrine Synthesis and Release. Norepinephrine (NE) is the primary neurotransmitter for postganglionic sympathetic adrenergic nerves. It is synthesized inside the nerve axon, stored within vesicles, then released by the nerve when an action potential travels down the nerve.

All these research and findings were done  in the based of book by Andrew Solomon- THE NOONDAYDEMON
The whole book is based upon the anatomy of depression, and it is a  must have on your collection.According to him anything can be change. One of top  pick  he has said is the language,used in training doctor, and increasingly,innonad-academic writing  and writing and conversations strangely perverse.                                 

Working through a mild depression without medications has certain advantages. It gives you the sense that you can correct your own chemical imbalances through the exercise of your own chemical will.

Anything can be changed, and we must understand the human organism as a sequence of selves that succumb to or choose one another. And yet the language of science, used in training doctors and, increasingly, in nonacademic writing and conversation, is strangely perverse.

The cumulative results of the brain’s chemical effects are not well understood. In the 1989 edition of the standard Comprehensive Textbook of Psychiatry, for example, one finds this helpful formula: a depression score is equivalent to the level of 3-methoxy-4-hydroxyphenylglycol (a compound found in the urine of all people and not apparently affected by depression); minus the level of 3-methoxy-4-hydroxymandelic acid; plus the level of norepinephrine; minus the level of normetanephrine plus the level of metanepherine, the sum of those divided by the level of 3-methoxy-4-hydroxymandelic acid; plus an unspecified conversion variable; or, as CTP puts it: “D-type score = C1 (MHPG) – C2 (VMA) + C3 (NE) – C4 (NMN + MN)/VMA + C0.” The score should come out between one for unipolar and zero for bipolar patients, so if you come up with something else – you’re doing it wrong. How much insight can such formulae offer? How can they possibly apply to something as nebulous as mood? To what extent specific experience has conduced to a particular depression is hard to determine; nor can we explain through what chemistry a person comes to respond to external circumstance with depression; nor can we work out what makes someone essentially depressive.

Returning from distress by gradual degrees gives sense to affliction itself.

Depression claims more years than war, cancer, and AIDS put together. Other illnesses, from alcoholism to heart disease, mask depression when it causes them; if one takes that into consideration, depression may be the biggest killer on earth.

He golden MD · Professor and Vice Chair of Research, Department of Neurological Surgery, School of Medicine · Professor, Department of Pathology, incdent, This is one of the best professor in the subject I have come across the topic. I have read his book about the anatomy of depression, called a noonday demon.He his writtings are his personal account of his own life and he is not ashamed of admitting him being gay.

Dr. Andrew Solomom=

In 2014, he was elected President of the Ohio State Neurosurgical Society (OSNS). OSNS supports patient and members in advancing patient care through the encouragement of education and research by allowing neurosurgeons in achieving the highest possible standards of professional ability and integrity.

depression is a silent killer

In 2014, he was elected President of the Ohio State Neurosurgical Society (OSNS). OSNS supports patient and members in advancing patient care through the encouragement of education and research by allowing neurosurgeons in achieving the highest possible standards of professional ability and integrity.


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